Glutathione

This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features:Summarizing the way glutathione is involved in stress responsesCompiling the multiple ways glutathione affects inflammatory responsesDisclosing how glutathione dampens programmed cell death such as ferroptosisExploring the enigma of how enzymes accelerate glutathione-dependent processesDiscussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reductionHighlighting the medical impact of glutathione-related metabolic pathwaysIllustrating the role thiol metabolism of pathogens might play in drug discovery