Thrombin &; Singlet Oxygen (1 O2*) Main Factors of Hemostasis

Neutrophil granulocytes (PMN) are our primary defence cells against bacteria, fungi, parasites, or micro-thrombi. Their main weapons and signals are the reactive oxygen species (ROS), H2O2 being mother ROS, radicalic OH and non-radicalic 1 O2* being the two daughter ROS. 1 O2* is the most important ROS because it is harmful against "non-self" and harmless against "self". 1 O2* is highly reactive against S-H, S-S, or C=C groups and releases photons (h ). The activation of the assembly of their NADPH-oxidase, one main trigger (zymosan A) and one main primer (1 O2*/hv) are of great physiological and pathophysiological importance in inflammation and in hemostasis. There is photonic communication: the neutrophils generate different types of photons and they can "see" them in other cells. The approximate 300-400 nm photons are the main signals and the photons of lowest wave length seem to especially alert them in emergency.