Streptomyces : Molecular Biology and Biotechnology

Streptomycetes are unusually complex bacteria that are abundant in soil. They grow as branching filaments and form chains of spores. Most importantly, they have an extraordinary ability to make antibiotics, for which they are the main industrial source, as well as other metabolites with medicinal properties. In recent years, the search for new antibiotics and other drugs in streptomycetes has been augmented by genomic studies, genome mining, and new biotechnological approaches. With contributions from some of the leading scientists in the field, this book documents recent research and development in streptomycetes genomics, physiology, and metabolism. With a focus on biotechnology and genomics, the book provides an excellent source of up-to-date information. Topics include: genome architecture * conjugative genetic elements * differentiation * protein secretion * central carbon metabolic pathways * regulation of nitrogen assimilation * phosphate control of metabolism * gamma-butyrolact