Molekulyarnye Aspekty Razvitiya Papillyarnykh Kartsinom Shchitovidnoy Zhelezy

V rabote rassmotreny molekulyarnye aspekty razvitiya i formirovaniya fenotipa papillyarnykh kartsinom shchitovidnoy zhelezy. Privedeny dannye o raznykh geneticheskikh narusheniyakh (tochechnykh mutatsiyakh i strukturnykh perestroykakh), kotorye identifitsirovany v dannykh opukholyakh, ikh chastote, spetsifichnosti, a takzhe faktorakh, privodyashchikh k generatsii takikh onkogenov v tireoidnykh kletkakh. Obsuzhdeny mekhanizmy vliyaniya onkogenov na protsessy transduktsii vnutrikletochnykh signalov, ekspressiyu tireoidspetsificheskikh belkov i transkriptsionnuyu aktivnost' retseptornykh tirozinkinaz. Osoboe vnimanie pri etom udeleno razlichiyam realizatsii onkogennykh effektov v dobrokachestvennykh i zlokachestvennykh opukholyakh shchitovidnoy zhelezy. Zatronuty sovremennye napravleniya razvitiya targetnoy terapii differentsirovannogo raka shchitovidnoy zhelezy i potentsial'nye vozmozhnosti primeneniya molekulyarno-biologicheskikh issledovaniy pri razrabotke metodov takogo lecheniya. Proanalizirovany dannye o chastote, formakh i mekhanizmakh vozmozhnogo vliyaniya razlichnykh patologicheskikh protsessov v shchitovidnoy zheleze na fenotip papillyarnogo raka. Ochercheny aktual'nye napravleniya sovremennykh issledovaniy i predstavleny potentsial'nye algoritmy ikh realizatsii.