Efficacy of Praziquantel, the Antischistosomal Drug : Determination of the Efficacy of Different Doses of Praziquantel (PZQ) on BALB/c mice Infected with Schistosoma mansoni

This book will practically take you through the disease process of the neglected tropical disease, schistosomiasis, also known as 'Bilharzia' and treatment regimens by praziquantel (PZQ) the antischistosomal drug of choice. Schistosomiasis ranks second to malaria in parasitic disease morbidity. It has claimed approximately 300,000 lives. The study highlighted in this book adopts the mouse model and the snail of the Genus Biomphalaria to demonstrate establishment of schistosomiasis and the disease's steady development as it would do in the human body. This study sounds the alarm signalling the siege of the broadly effective PZQ. This is because standard doses of PZQ do not clear the schistosomiasis parasite from the patient's system. In this study, higher doses of PZQ are administered and the disease process is monitored against the different drug doses.