Study the Effect of Formulation and Inprocess Parameters on Pellets : Extrusion and Spheronization Techniques

This study was to investigate the effect of formulation variables like Microcrystalline cellulose (MCC), Lactose, Dicalcium phosphate dihydrate (DCPD), Starch 1500, Pearlitol 200sd etc. which are widely used tabeleting excipients. These diluents were used individually and in combination with MCC. Binders like Hydroxypropyl cellulose (HPC-sL), Polyvinylpyrrrolidone-K 30, were used to study their effect on pellet properties. The pellets prepared were analyzed for the properties like their shape (aspect ratio), size distribution, smoothness, bulk density, tapped density, car index, hausner ratio, Loss on drying and yield.