Formulation and Evaluation of Celecoxib Gel : Celecoxib Transdermal Gel

Drug delivery through the skin has been a promising concept. Transdermal gel preparations are intended for superficial skin application, mucosal surfaces for local action or skin penetration of medicament or for their soothing or protective action. NSAID's are having excellent anti-inflammatory and analgesic activity but NSAID's produces various adverse effects and to avoid this alternate routes of administration have been tried. The aim of this study was to develop suitable transdermal gel formulations of celecoxib using various gelling agent with and without permeation enhancers, which would attenuate the gastrointestinal related toxicities associated with oral administration Celecoxib is a highly selective COX-2 inhibitor. In the present study gel with different concentrations of carbapol, sodium alginate and sodium CMC were prepared. Gels were subjected for various evaluation tests. The gel formulation consisting of 7.5% w/w sodium alginate with DMSO found to be suitable for topical application based on in vitro evaluation.