Cancer, Diabetes, Alzheimer's and Cardiovascular - The Swing of Connection

Here we have developed a structure based analysis to address two problems of protein understanding that would give us an insight about various disease correlation, firstly is there any relation between the common receptor proteins that play a major role in Diabetes, Alzheimer, Cancer and Cardiovascular disease? And secondly are there any point mutations in the conserved regions of these receptor proteins which might bring this kind of correlation between the diseases?