Comprative Study on Effect of Natural &; Synthetic Superdisintegrants : Comparison of Diclofenan Mouth Dissolving Tablet with Fenugreek and Sodium Starch Glycolate as Superdisintegrants

The study was undertaken with an aim to formulate Mouth Dissolving tablets of Diclofenac Sodium containing Fenugreek and SSG as natural and artificial superdisintegrant respectively and to compare its release profile with the same. Granules were evaluated for tests, bulk density, tapped density, compressibility index and hausner ratio before using punched as tablets. In vitro dissolution test are found for 6 batches. From these results AF6 was selected as optimized formulation. All the formulation shows the good blend properties for direct compression and hence tablets were prepared by using direct compression technology. This rapid disintegration of the FDTs was due to the penetration of saliva into the pores of the tablet, which lead to the swelling of superdisintegrant to create enough hydrodynamic pressure for quick and complete disintegration of the tablet. Fenugreek was effective. Hence it can be concluded that instead of using artificial superdisintegrant, we use should natural because they give better dissolution profile, are cheaper, abundantly available, non toxic and non-irritating in nature.