Natural & Synthetic 1-Phenylnaphthalene Lignans : Study of Immunomodulatory activity of naturally occurring and related synthetic 1-Phenylnaphthalene lignans

1-Phenylnaphthalene and Pericarbonyl lactone lignans are synthesized by green chemistry and the lignans having similar 1-Phenylnaphthalene skeleton are extracted from two plants-Ruta graveolens Linn. and Jatropha gossypifolia Linn using soxhlet assembly.These natural and synthetic lignans were then tested for their immunomodulatory potential. Starting with -benzoyl propionic acid and aryl aldehydes, -arylidine--phenyl-,,-butenolides were synthesized. The lactone ring of butenolides is opened to get the keto acid i.e. -arylidine--benzoyl propionic acid. Cyclization of above keto acid as well as its derivatives with sulphamic acid catalyst under microwave radiation ultimately lead to 1-Phenylnaphthalene systems. The immunomodulatory activity of the 1-Phenylnaphthalene systems is studied by the two methods-"Spleen cell proliferation" and "Effect on serum immunoglobulins". It is found to be quite significant in both synthetic compounds as well plant extracts. The findings suggest that 1-Phenylnaphthalene lignans can positively modulate the immunity of the host.