Pharmacological Investigations of Asteracantha Longifolia : To observe Analgesic, Anti-inflammatory and CNS effects

The present study was designed to evaluate the CNS,analgesic and anti-inflammatory activities of Asteracantha longifolia Nees in mice. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate, formalin and acetic acid test in mice. Anti inflammatory effects were determined by croton oil, xylene, carrageenan and cotton pellet.CNS effects are determined by rotarod, elevated plus maze, open field, swimming test and hole cross test.The results of the present study demonstrate that the extract has no effect on CNS but produce analgesic and anti-inflammatory action in mice. These data demonstrated that the plant may contain bioactive compounds possessing anti-inflammatory and analgesic activities that could be a potential source for discovery of newer analgesic and anti-inflammatory "leads" for drug development.