Wilms' Tumor Gene 1 as an Immunotherapeutic Target in Uterine Cancer

Uterine high grade sarcoma and recurrent endometrial carcinoma are aggressive cancers with limited classical treatment options, resulting in a poor prognosis. The search for targeted treatments is urgently needed. In this research we focused in the first place on the detection of the highly immunogenic tumor-associated antigen Wilms' tumor gene 1 (WT1) in uterine tumors. The next step was to develop a targeted treatment against WT1, based on dendritic cell immunotherapy.