Melt-In-Mouth (MIM) Drug Delivery System : Formulation and Evaluation of Topiramate Melt-In-Mouth Tablets

Melt-In-mouth (MIM) technology is an innovative technology, which allows tablet to disintegrate rapidly, usually in a matter of seconds, without the need for water, providing optimal convenience to the patient. Topiramate is antiepileptic drug prescribed extensively for the patient of partial onset seizures, or primary generalized tonic-clonic seizures in both children and adults, is extremely bitter resulting in poor patient compliance. Recently, a number of novel techniques for bitterness inhibition in formulations intended for pediatric and geriatric patients need acceptable taste. In the present study, an attempt was given to mask bitter taste of topiramate by kyron T-114 (Cation exchange resin). We sincerely hope that this book will helpful to student as well as industry and academic professionals involved in pharmaceutical and other related science.