Selective Reduction of C=c Double Bond of the Lactone Ring

Bok av Bidar Morteza
The aim of the current work is development of the novel methods for the selective reduction of the double bond of lactone ring in 3-substituted 2-oxo-2,5-dihydrofurans and 2-oxo-5,6-dihydropyrns, as well as the synthesis of new derivatives of unsaturated -lactones on the basis of relatively accessible compounds of butenolide class, with the aim of searching for the biological activity among the synthesized structures.Two reducing systems -"magnesium-methanol" and "sodium borohydride-triethylamine" - are proposed for the selective reduction of C=C double bond of the lactone ring.