Synthesis of Quinolinyl Ureas Via Pd Catalyzed C- N Coupling

An efficient catalytic system for the synthesis of quinolinyl ureas have been developed using Pd based catalyst system. All these synthesized quinolinyl ureas have adequate pledge as active drug candidates via a novel process. The in vitro biological screening data of the newly synthesized analogs revealed that majority of the compounds have demonstrated noticeable antimicrobial against various panels of microorganisms.