The association between circulating levels of myeloperoxidase and type 2 diabetes in the Malmö diet and cancer cohort. An Assessment

Seminar paper from the year 2016 in the subject Medicine - Internal Medicine, grade: 1, Lund University, course: Master Thesis, language: English, abstract: Chronic inflammation is suggested to play an important role in the pathogenesis of many chronic conditions. Chronic inflammatory biomarker Myeloperoxidase (MPO) has been reported in several studies that have investigated its role in cardiopulmonary events. However, there are limited studies that investigated its relationship with type 2 diabetes.In this text the relationship between plasma MPO concentration and lifestyle and socioeconomic factors and incident type 2 diabetes mellitus in the Malmö diet and cancer cohort (MDC) will be investigated. In order to do this a prospective cohort study of 4544 participants was drawn from MDC cardiovascular sub-cohort, with no type 2 diabetes at baseline between 1991 and 1996. Plasma MPO concentration were measured using Olink CVD kit. The cox proportional hazard regression analysis was used to determine the relationship of plasma MPO concentration with incident type 2 diabetes.