The Development of Iron Chelators for the Treatment of Cancer : Aroylhydrazone and thiosemicarbazone chelators for cancer treatment

This monograph describes the development of novel NT and DpT series aroylhydrazone and thiosemicarbazone iron chelators for the treatment of cancer. It neatly reviews the role of iron in cancer and the development of chelators for cancer treatment before describing the synthesis and biological activity of the NT and DpT series of chelators in both in-vitro and in-vivo models of cancer. The authors conclude that the DpT series, in particular, may be clinical potential in the treatment of cancer.