Neurons At The Gate : Intrinsic and synaptic properties of the neurons in mouse barrel cortex

The rodent barrel cortex, with its unique morphological structure and clearly defined anatomical map corresponding to its functional layout, is widely used for studies of the structure and function of the neocortex, integrated with quantitative behavioral analyses and defined molecular manipulations. These studies bring us nearer to an understanding on the molecular level of how neuronal activity generates sensory perception and behavior. In my work, I have focused on cellular and molecular features of neurons composing the rodent barrel cortex, and their synaptic connectivity. My work centers on (A) the synaptic properties of the neurons composing Layer 4 local excitatory circuits, (B) excitatory receptors which mediate propagation within these circuits in adult animals, and (e the factors that regulate development of these recurrent excitatory circuits.