Effect of Super Disintegrants on Rapid Release Tablets of Aceclofenac : RAPID RELEASE TABLETS FORMULATION AND EVALUATION

Rapid release tablets are preferred by most physicians because of their ability to attain peak plasma concentration rapidly, by immediately disintegrating in gastric fluid. Pain and inflammation are one of the most common conditions where rapid action of drug is required. Aceclofenac is used for various pain and inflammatory conditions, with fewer side effects than diclofenac. Aceclofenac is completely absorbed after oral administration. There are no immediate release tablets of aceclofenac in market. In order to accomplish that task of the formulation of rapid release tablets and to study the effect of increasing concentrations of super disintegrant, different formulations were prepared with different drug: disintegrants ratio. The various super disintegrants used were indion- 414 , crospovidone, crosscarmellose sodium and sodium starch glycolate. The formulated tablets were evaluated for different characteristics. The different parameters like thickness, friability, hardness, weight variation, drug content were found within limits. Dissolution profile was studied using USP-2 dissolution apparatus.