Pharmaceutical Study of Different Bioadhesive Delivery Systems : Formulation, Evaluation

Nasal route for drug administration has an advantage of introducing the drug directly into the systemic circulation without passing through the liver so it eliminates the first pass effect. In addition to its high absorptive surface, rich circulation which increases both rate and extend of drug absorption. Bioadhesive gel is an ideal dosage form for the nasal route as it keeps the drug in contact with the nasal mucosa for prolonged time by decreasing the nasal mucocillary clearance so elongates the nasal residence time allowing for increased absorption and increased bioavailability. Bioadhesive suppositories ensure the adhesion and placement of the suppositories in the lower part of the rectum. The aim of this work is trying to increase Verapamil HCl bioavailability by avoiding its first pass effect in a rapid manner this is achieved by formulating bioadhesive nasal gels formulae and bioadhesive suppository formulae.