Formulation of Particles for Pulmonary Drug Delivery : Effect of particle morphology on inhalation efficiency

The study focuses on the formulation of particles for pulmonary drug delivery. The effect of particle shape and morphology on inhalation efficiency has been investigated. Carrier and drug model particles are formulated with a number of different surface morphology. Flowability, aerosolization and deposition behavior of particles with similar size range are investigated through in vitro experimentations. This study successfully optimizes that pollen-shape particle with fibrous surface morphology as optimum particle shape with favorable characterizing properties.