Hypolipidemic Activity of Diclofenac with Pioglitazone and Bezafibrate : Basics, Concepts, Materials and Methods

Excessive amount of lipid-intake may result in hyperlipidemia, which is characterized by an abnormal elevation in one or more of the serum lipids such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and triglycerides (TG). Hyperlipidemia is considered to be a major risk factor for cardiovascular diseases including atherosclerosis, myocardial infarction, heart attacks, and cerebrovascular diseases. Coronary heart disease (CHD) due to atherosclerosis is the leading cause of mortality in the United States and results in about 500,000 deaths each year. The circulatory system disorders are going to be the greatest killer in India by the end of year 2015 (kaul, Sapra and Ghosh, 1998). High saturated fat diet involved in the development of hypertension.