Kletochnye Membrany Pri Atopicheskikh Boleznyakh U Detey

V monografii predstavleny dannye original'nogo issledovaniya kliniko-patogeneticheskoy roli plazmaticheskikh membran eritrotsitov i limfotsitov u detey s atopicheskimi zabolevaniyami (atopicheskom dermatitom, bronkhial'noy astmoy, pollinozom). Pokazano, chto u detey s atopicheskimi boleznyami imeyutsya odnonapravlennye osobennosti molekulyarnoy organizatsii i lipidnogo spektra membran eritrotsitov i limfotsitov. Ustanovleno, chto osnovnym komponentom vovlecheniya plazmaticheskikh membran v patogenez atopicheskikh zabolevaniy u detey yavlyayutsya konstitutsional'nye osobennosti ikh molekulyarnoy struktury, markerami chego yavlyayutsya snizhenie mikrovyazkosti poverkhnostnykh sloev membran, narushenie vzaimodeystviya membrannykh proteinov s lipidami so snizheniem pogruzhennosti perifericheskikh belkov v lipidnyy bisloy, snizhenie membrannogo kholesterina i izmenenie sootnosheniya fosfatidiletanolamina i fosfatidilkholina.