Pharmacokinetic Interaction Between Carbamazepine and Ciprofloxacin : Carbamazepine & Ciprofloxacin Metabolism

Drug-drug interactions are causing morbidity and mortality in mankind. Severe harmful interactions are recoded when drugs are prescribed without studying their pharmacokinetic and pharmacodynamic actions. Knowledge about drug interactions is necessary for pharmaceutical industries, regulatory agencies, clinical health care professionals and policy makers. The book focuses on research findings regarding influence of Fluoroquinolone (Ciprofloxacin) on the pharmacokinetics of Carbamazepine, investigated in healthy adult males. Carbamazepine is mostly prescribed drug for the treatment of epilepsy, neuropathic pain, schizophrenia, phantom limb syndrome and paroxysmal extreme pain disorder. Epileptic patients can have various types of infections like urinary tract, upper respiratory tract, skin and soft tissue, dental pain, typhoid and other infectious diseases. These patients often injured during fits and fluoroquinolones are used as first line of therapy to treat such kind of infectious disease. Since both drugs are prescribed commonly by the physicians and interaction may result, so the information about their pharmacokinetics given here are beneficial for physicians and researchers.