Molekulyarnaya Genetika Shtammov Streptococcus Pneumoniae

V monografii proanalizirovana soputstvuyushchaya infektsionnaya zabolevaemost' dykhatel'nykh putey u detey, boleyushchikh tuberkulezom, pokazana struktura nositel'stva uslovno-patogennykh mikroorganizmov verkhnikh dykhatel'nykh putey u dannoy gruppy patsientov. Provedeny molekulyarno-geneticheskie issledovaniya shtamov Streptococcus pneumoniae, vydelennykh u bol'nykh i nositeley, boleyushchikh tuberkulezom. Issledovan serotipovoy sostav shtammov pnevmokokkov, antibiotikorezistentnost', faktory virulentnosti metodami PTsR, Multiplex PTsR, sekvenirovaniya uchastkov genoma pnevmokokka. Vyyavleno, chto gruppoy riska po razvitiyu pnevmokokkovykh infektsiy yavlyayutsya ne tol'ko patsienty, no i medpersonal protivotuberkuleznykh statsionarov, gde tsirkuliruyut vysokovirulentnye shtammy pnevmokokka, obladayushchie polirezistentnost'yu k antibiotikam, v tom chisle i k rifampitsinu - antibiotiku shirokogo spektra deystviya, kotoryy primenyaetsya dlya lecheniya tyazhelykh infektsiy, v tom chisle i tuberkuleza. Obosnovyvaetsya neobkhodimost' vaktsinatsii dannykh grupp riska protivopnevmokokkovoy vaktsinoy. Prednaznacheno dlya pediatrov i drugikh vrachey prakticheskogo zdravookhraneniya, bakteriologov.