Artocarpus Heterophyllus Mucilage as a Tablet Binder : Isolation and Evaluation of Artocarpus heterophyllus fruit mucilage as a tablet binder

Artocarpus heterophyllus found wild in the forest region, fruit are multiple seeded containing mucilage. Acetone precipitation method is used to isolate mucilage. The physicochemical characteristic of mucilage has performed such as swelling index, solubility, LOD. This study was carried out to compare the binding effects of isolated mucilage with starch. Granule properties such as angle of repose, moisture content, bulk and tapped densities, Hausner's ratio, Carr's index and tablet properties using standard methods. Mucilage of varying concentrations of 4, 6 and 8%w/w were used to produce paracetamol granules by wet granulation method and compressed. An increase in binder concentration led to decrease in friability and increase in disintegration time of the tablets. The results indicate that mucilage obtained from Artocarpus heterophyllus fruit possesses comparable binding properties.