Antiepileptic and Antipsychotic Activities of Oxalis Corniculata Linn : Its neuropharmacological properties possibly mediated via facilitation of GABA transmission & blockade of D2 receptor

Acute and chronic administration of Oxalis corniculata L. has anti-epileptic activity against MES and INH induced convulsions by reducing tonic hind limb extension phase and delaying onset of convulsion. It also observed that plant extract possess anti-psychotic activity against apomorphine induced stereotyped behavior and haloperidol induced catalepsy by reducing the stereotyped behavior as well as potentiated the cataleptic score. Anti-epileptic activity of Oxalis corniculata L. may be attributed to the involvement of either by blocking the Na+ channels or enhancing the GABAergic system in the neuronal of the brain. Furthermore, anti-psychotic activity of Oxalis corniculata may be due to involvement of dopaminergic pathway. The identification of active constituents with anti-epileptic and anti-psychotic activity from this plant may provide new directions for identification of active neuropharmacological agents, which could be given concomitantly during epilepsy and psychosis. These results suggest that the Oxalis corniculata L. have potential clinical application in the management of epilepsy and psychiatric disorders.