Determination of Drugs Using Capillary Electrophoresis : Analytical Method Development and Fundamental Studies on the Separation of Drugs using Capillary Electrophoresis

Capillary electrophoresis (CE) is slowly becoming a mainstream analytical technique. This book highlights several unique studies of CE for the determination of drugs. The lack of sensitivity of the CE technique is overcome by the use of an innovative liquid-phase microextraction technique for the trace determination of the anti-diabetic drug, rosiglitazone in biological fluids. For non-chromophoric compounds, the use of the capacitively coupled contactless conductivity detector offers an interesting option. This is demonstrated in the determination of the -blocker drugs (atenolol, chlorthalidone and amiloride), the antiviral drugs acyclovir and valacyclovir and their major impurity (guanine) in pharmaceutical preparations. The separation of the enantiomers of both ofloxacin and ornidazole or modafinil are also described. The computational calculations for the enantiomeric inclusion complexes for a few of these drugs and binding constant measurements were also measured. This book will provide researchers, students, chemists, pharmacists, and scientists valuable insights into the fundamentals and applications of CE in drug analysis.