New Spectrophotometric Method for Determination of Cephalosporines : Spectrophotometric determination of cefadroxil

The importance of cephalosporins and the continuing introduction of new drugs of this series have prompted many researches to explore methods for their determination. Cefadroxil, one of these drugs, is the target in the present work. Most of the reported methods of analysis of cefadroxil are time consuming, lacking selectivity, require sophisticated equipment or not simple for routine analysis. For instance, the most widely used technique for its determination is liquid-chromatography. Therefore the need for a fast, sensitive, simple and selective method is needed, especially for routine quality control analysis of pharmaceutical products containing cefadroxil. The penicillins and the cephalosporines share a common structural feature that makes them determined by the proposed method. In this study, simple spectrophotometric method was developed for the assay of cefadroxil in bulk and pharmaceutical dosage forms. The validity of the method for the determination of cefadroxil in bulk form and capsule form was assessed by statistical comparison of the results with those obtained by the official HPLC method.