Impact of Diabetes Type2 in the Activity of G6pd in Human Erythrocytes

Diabetes mellitus is a metabolic affliction saunter that is characterized by a nobler than normal blood glucose poise. Glucose-6-phosphate dehydrogenase (G6PD) enzyme code (E.C.1.1.1.49) is an underlying enzyme in the phosphogluconate pathway. In this study, G6PD vitality in the mortal erythrocyte of male and female patients with type 2 diabetes mellitus was assessed utilizing a spectrophotometer at 340 nm. The activity of the enzyme increased with elevated glycated hemoglobin (HbA1C) levels. G6PD activity was found to be significantly associated with type 2 diabetes mellitus. The association between G6PD and diabetes mellitus was significant (P < 0.001). moreover, g6pd was positively correlated with hba1c levels (r = 0.572). the following mean standard deviation values were obtained: g6pd activity (iu/g hb), 3.1103 0.79349; hba1c (%), 8.6600 1.63120; hb (g/dl), 13.4933 1.38836; platelet count (103/l), 283.4667 58.59312; wbc (103/l), 7.4890 1.49842; hct (%), 45.0100 2.63430; and bs (mg/dl), 230.2667 75.67760. the results showed that an elevated hba1c up leads to increased g6pd performance in the human erythrocyte, which is concerning to glucose levels.