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This book contains papers presented by leading experts at the "Interdisciplinary Workshop on Mathematical Methods in Biomedical Imaging and Intensity-Modulated Radiation Therapy (IMRT)" held at the Centro di Ricerca Matematica (CRM) Ennio De Giorgi at Pisa, Italy, from October 15 to 19, 2007. The interdisciplinary book consists of research and review papers by leading experts and practitioners in biomedical imaging and intensity-modulated radiation therapy (IMRT).